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central proteomics facilities pipeline  (SourceForge net)
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SourceForge net central proteomics facilities pipeline
<t>Proteomics</t> elucidates function and mechanism in molecular endocrinology. The schematic shows events on which proteomics reports in general functional models of G protein-coupled receptor and NR signaling. The binding of a variety of peptide ligands to G protein-coupled receptors (GPCR) induces recruitment of intracellular interacting partner proteins, touching off a variety of kinase cascades with functional endpoints in the cytoplasm (phosphorylated target protein) and nucleus. Nuclear targets of kinase cascades include transcription factors (TF), NR, and coregulators (CoR), which collectively modulate target gene expression and de novo protein synthesis. NR ligands bind directly to NR (the classic genomic model), inducing the recruitment of coregulators and modulating expression of target genes. Certain NR ligands have also been reported to elicit rapid cellular effects via cross talk with cellular kinase cascades (the nongenomic model). Phosphorylation events upon which phosphoproteomics reports are indicated.
Central Proteomics Facilities Pipeline, supplied by SourceForge net, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Proteomics elucidates function and mechanism in molecular endocrinology. The schematic shows events on which proteomics reports in general functional models of G protein-coupled receptor and NR signaling. The binding of a variety of peptide ligands to G protein-coupled receptors (GPCR) induces recruitment of intracellular interacting partner proteins, touching off a variety of kinase cascades with functional endpoints in the cytoplasm (phosphorylated target protein) and nucleus. Nuclear targets of kinase cascades include transcription factors (TF), NR, and coregulators (CoR), which collectively modulate target gene expression and de novo protein synthesis. NR ligands bind directly to NR (the classic genomic model), inducing the recruitment of coregulators and modulating expression of target genes. Certain NR ligands have also been reported to elicit rapid cellular effects via cross talk with cellular kinase cascades (the nongenomic model). Phosphorylation events upon which phosphoproteomics reports are indicated.

Journal: Molecular Endocrinology

Article Title: Minireview: Progress and Challenges in Proteomics Data Management, Sharing, and Integration

doi: 10.1210/me.2012-1180

Figure Lengend Snippet: Proteomics elucidates function and mechanism in molecular endocrinology. The schematic shows events on which proteomics reports in general functional models of G protein-coupled receptor and NR signaling. The binding of a variety of peptide ligands to G protein-coupled receptors (GPCR) induces recruitment of intracellular interacting partner proteins, touching off a variety of kinase cascades with functional endpoints in the cytoplasm (phosphorylated target protein) and nucleus. Nuclear targets of kinase cascades include transcription factors (TF), NR, and coregulators (CoR), which collectively modulate target gene expression and de novo protein synthesis. NR ligands bind directly to NR (the classic genomic model), inducing the recruitment of coregulators and modulating expression of target genes. Certain NR ligands have also been reported to elicit rapid cellular effects via cross talk with cellular kinase cascades (the nongenomic model). Phosphorylation events upon which phosphoproteomics reports are indicated.

Article Snippet: Central Proteomics Facilities Pipeline (CPFP) , Suite for labeled or label-free quantitation in core proteomics facilities , http://cpfp.sourceforge.net ( 124 ).

Techniques: Functional Assay, Binding Assay, Targeted Gene Expression, Expressing, Phospho-proteomics

Selected MS data analysis pipeline suites

Journal: Molecular Endocrinology

Article Title: Minireview: Progress and Challenges in Proteomics Data Management, Sharing, and Integration

doi: 10.1210/me.2012-1180

Figure Lengend Snippet: Selected MS data analysis pipeline suites

Article Snippet: Central Proteomics Facilities Pipeline (CPFP) , Suite for labeled or label-free quantitation in core proteomics facilities , http://cpfp.sourceforge.net ( 124 ).

Techniques: Labeling, Quantitation Assay, Multiplex sample analysis, Phospho-proteomics, Biomarker Discovery